Thanks for the explanation, it's a basic workshop just working on old cars.
I do a lot of automotive work, too. My eyes aren't getting any younger, and I really love the quantity & quality of light in my shop. I do still drag out a work light when I'm working between the car & wall, under the hood, or under the car, but otherwise the light is great.
When doing woodworking, the even spread of light is wonderful to have.
Before I try again with the software it shows over 120 light fittings for my 80x40x14. Can I use higher lumen LED lights wider spaced, say 8400 lumen lights instead per 50 sq/ft. And half or more the amount of light fittings I need to wire in? Though I get that the fewer lights the more shadows, if I dropped it to approx 60 fittings would i notice it? The doors are on the long wall so I'd like to mount the lights to the trusses, 90 degrees to what the software shows. Does that make any difference?
As you mentioned, reducing the number of fixtures to provide the same lumens will only create more shadows and hot spots. The light won't be spread quite as evenly. The design you posted above shows 24 fixtures. Where'd 120 come from?
Rotating your fixtures 90 degrees with respect to the software plan will also make sharper shadows because your lights will be in long strips.
Will you notice the difference? That depends on how picky you are, and whether you've ever experienced anything better. I'm a photographer, so I'm constantly aware of lighting conditions everywhere I go. That can be a curse sometimes.
However, if your ceiling consists of just open trusses with no structural support between them, then there's a huge advantage to simply running the lights & wires in parallel along the bottom of each truss, even if it means spacing them 8' apart. I'd probably do that if I were you. In my shop, there's an attic above the shop, so I have floor joists every 16" across my entire ceiling. I was able to put my fixtures and run my wires pretty much anywhere I wanted. Attached is a photo taken right after I first hooked up the lights.
Are your big doors overhead or sliders? If overhead, how often will you be trying to work while they're open? An open overhead door will block an awful lot of light. I'm not sure if you have the flexibility to position your lights around that, but it's something to consider.
The only 80x40 on this thread is back in 2015 and it sadly doesn't use LED lights in the planning.
LED vs fluorescent tube doesn't matter, except in the energy used & the cold weather start-up time. They'll cast the same light.
Speaking of energy used, pay attention to the current used by each fixture and how many separate lighting circuits you'll need to feed your entire ceiling. My 35 fixtures filled a single 15A circuit.
Another thing I did with my 35 fixtures was to split them up into 3 switches. One switch is a 3-way with illuminated switches at every door. (I *love* those illuminated switches!) That switch controls just 4 fixtures spaced evenly around the entire shop. I use that switch when I'm just running in to grab a tool or something and don't need to light everything like day.
A second switch (only by the main door) controls the remaining fixtures in the front half of my shop. A third switch (also only by the main door) controls the remaining fixtures in the back half of my shop.
The wall switches for my overhead garage door openers also have motion sensors on them that will turn on the small lights in the openers whenever something in the shop moves. I didn't request that, but it's been nice to have.
The ability to control the lighting like that has come in really handy on several occasions--not the least of which has been during several graduation parties when we were running a projected slide show at one end of the shop and needed it darker back there.